The first one I remember was Perry Cuda. I'm sure there were others before him, but back then recruiting didn't take place under the spotlight it does now.
This is true in two ways.
1) Back in the days of unlimited scholarships, it was both pretty easy to land big names AND very easy to overcome "that guy didn't work out" because you had an endless supply of players.
2) Our evaluations of players have become better and more refined over time.
Once upon a time the now "five stars" were called "blue chippers" (showing my age here) and while, yes, it was a big deal when a particular blue chipper went to a school, the reality was more "so what" than it is now. Nowadays, you have to have a top 10 recruiting class (or close to that) for a few years to contend for the national championship. For years - until recently - I always rolled my eyes because I'm old enough to remember when the Notre Dame teams of Gerry Faust would land "the best recruiting class in the country" every year he was there - and they never had more than 7 wins or fewer than 5 imperfections (including ties) during his tenure.
I read Colorado Coach Bill McCartney's autobiography ("From Ashes to Glory"), and I recall him talking about how difficult recruiting actually was - unless you were Notre Dame. The Irish - back then - could basically say "we want him and him and him" and just so long as they could meet the academic requirements, they were going to Notre Dame. He had to do the biggest selling job of all-time to help land Anthony Carter...because Bo and Michigan didn't throw the ball before Carter arrived.
My point? Misses didn't matter prior to the 80s all that much because the Blue Bloods had an endless supply of talent (Bryant used six QBs in 1981) - and the game was more of a running back's game than it is now. The first "big one" I recall was Billy Ray in the late 80s around the time I was a senior in HS. And missing him was evident when we were throwing Vince Sutton (another miss), Jeff Dunn, and David Smith (lotta heart) out there, too.