News Article: Good luck dealing with a pandemic, depending on this administration...

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TIDE-HSV

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My coworker that had it said he cannot take a deep breath. He gave up smoking as a result.
Same thing with our friend, who already had complications from repeated bouts with pneumonia. She was not a smoker. She barely has wind for a phone conversation. She had an opportunistic bacterial infection as a followon...
 

TexasBama

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In the news here this morning it was reported that four hospitals are full, but which ones weren’t reported. Elective surgeries are a piece of this. OTOH, there are a lot of hospitals here.
 

NationalTitles18

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What you find in the lungs of people who have stayed with the disease for more than a month before dying is something completely different from normal pneumonia, influenza or the Sars virus,” he said. “You see massive thrombosis. There is a complete disruption of the lung architecture – in some lights you can’t even distinguish that it used to be a lung.

There are large numbers of very big fused cells which are virus positive with as many as 10, 15 nuclei,” he said. “I am convinced this explains the unique pathology of Covid-19. This is not a disease caused by a virus which kills cells, which had profound implications for therapy.”
 

TIDE-HSV

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What you find in the lungs of people who have stayed with the disease for more than a month before dying is something completely different from normal pneumonia, influenza or the Sars virus,” he said. “You see massive thrombosis. There is a complete disruption of the lung architecture – in some lights you can’t even distinguish that it used to be a lung.

There are large numbers of very big fused cells which are virus positive with as many as 10, 15 nuclei,” he said. “I am convinced this explains the unique pathology of Covid-19. This is not a disease caused by a virus which kills cells, which had profound implications for therapy.”
That is very interesting in view of the findings with our friend I keep mentioning. She had it way early, probably from the trip from Chicago beside the Italian man. She has not been tested yet for antibodies. When she had it, with all the symptoms and almost dying, there was no covid testing going on. When they biopsied her lungs, they found cells they couldn't identify and had never seen before...
 

TIDE-HSV

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It's going to be interesting to see where this leads scientifically.
When she was at her worst, they tested for flu, which was negative. She made her plane trip return by the Italian at the very end of February and came down with it about a week or so into March. They weren't testing for Covid then here. Her doc, an infectious disease specialist, thinks it was definitely Covid. She is a retired RN and pretty canny. When she went to the hospital for her first trip, she insisted that they mask her and put her in an isolation room...
 

Jon

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When she was at her worst, they tested for flu, which was negative. She made her plane trip return by the Italian at the very end of February and came down with it about a week or so into March. They weren't testing for Covid then here. Her doc, an infectious disease specialist, thinks it was definitely Covid. She is a retired RN and pretty canny. When she went to the hospital for her first trip, she insisted that they mask her and put her in an isolation room...
she likely saved multiple lives with that one decision
 

Crimson1967

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State reports 784 deaths.
 

CharminTide

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What you find in the lungs of people who have stayed with the disease for more than a month before dying is something completely different from normal pneumonia, influenza or the Sars virus,” he said. “You see massive thrombosis. There is a complete disruption of the lung architecture – in some lights you can’t even distinguish that it used to be a lung.

There are large numbers of very big fused cells which are virus positive with as many as 10, 15 nuclei,” he said. “I am convinced this explains the unique pathology of Covid-19. This is not a disease caused by a virus which kills cells, which had profound implications for therapy.”
I'm going to tone down the dramatization here a bit. A lot of viruses (herpes, CMV, etc) show these kinds of pathologic features, and multinucleated giant cells (as we call it in the business) are usually a reactive change that we see pretty frequently in areas of inflammation. Here's a nice picture from a COVID-positive lung biopsy. Panel B shows the multinucleated cells. Panel C shows the kind of changes we see in some other viral infections -- it's the big cell that looks like it has two eyes in the center of the panel (similar to the so-called Owl's Eye nuclei of CMV).



And if you want a (somewhat dry) tour of COVID lung pathology, you can watch the video below. The biggest practical issue is, of course, ARDS, which is source-agnostic (meaning lots of things cause it, as it's just a non-specific inflammatory state that impairs oxygen exchange).

 

UAH

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Thinking earlier that Trump has broken every rule in the accepted political playbook and still appears to survive. Bush 43 flew over New Orleans following Katrina and it follows him yet today. Trump bungles and ignores the greatest calamity to mankind in history and expects to be given a pass! He continues down that path in the new BLM crisis, bungles it yet again, and is still defended in the Senate. It makes me ashamed to think that I ever supported the Republican Party, whose basic political philosophy could allow it to sink to this level of putridness!
 
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crimsonaudio

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Coronavirus cases are spiking across the country and experts say Florida has the makings of the next epicenter

Florida has “all the markings of the next large epicenter of coronavirus transmission,” and risks being the “worst it has ever been,” according to Wednesday’s projections from a model put together by a team of scientists at Children’s Hospital of Philadelphia and the University of Pennsylvania.

The state joins nine others — Alabama, Arizona, California, Nevada, North Carolina, Oklahoma, Oregon, South Carolina and Texas — that are seeing record-high seven-day averages of new coronavirus cases per day, according to a CNN analysis of data from Johns Hopkins University.
 

92tide

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UAH

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our country is pretty much a failed state at this point. hopefully, we can make something out of the rubble.
One could pass over that as if it is a comment made out of frustration, but yet, we descend into third world status or worse, heavily mortgaging our future, and few even acknowledge the fact that the bill could be coming due over the next few years from the after effects of the pandemic. Washington fiddles as Rome burns around them.
 

chanson78

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One could pass over that as if it is a comment made out of frustration, but yet, we descend into third world status or worse, heavily mortgaging our future, and few even acknowledge the fact that the bill could be coming due over the next few years from the after effects of the pandemic. Washington fiddles as Rome burns around them.
Speaking of upcoming crisis, coronavirus is putting stress on bank debt.

 
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